An LDH (lactate dehydrogenase) test measures the amount of LDH in your blood or other body fluid to check for tissue damage. While it's normal to have some LDH in your blood or body fluids, when tissues in your body experience damage or injury, they release excess LDH into your bloodstream or other body fluids. Introduction Lactic acid is produced in physiologically normal processes, and as a common finding in disease states. When increased production is comorbid with decreased clearance, the severity of the clinical course escalates. What is Lactate? Lactate is a bi-product constantly produced in the body during normal metabolism and exercise. It does not increase in concentration until the rate of lactate production exceeds the rate of lactate removal which is governed by a number of factors. Blood lactate concentration ([La −] b) is one of the most often measured parameters during clinical exercise testing as well as during performance testing of athletes.While an elevated [La −] b may be indicative of ischemia or hypoxemia, it may also be a "normal" physiological response to exertion. In response to "all-out" maximal exertion lasting 30-120 seconds, peak [La −] b Lactate is mainly metabolised by the liver and partially by myocytes, though the kidney plays more of a role in metabolism in the presence of hyperlactataemia. Hyperlactataemia Hyperlactataemia reflects an imbalance between production and clearance of lactate. What is lactic acidosis? Lactic acidosis is a form of metabolic acidosis, a condition in which there's too much acid in the body. Lactic acidosis begins when a person's body makes too much It's a test that measures the amount of lactic acid (also called "lactate") in your blood. This acid is made in muscle cells and red blood cells. It forms when your body turns food into Lactic acid is a chemical your body produces when your cells break down carbohydrates for energy. You might see it referred to as lactate. Muscle cells and red blood cells make the most lactic acid, but it can come from any tissue in your body. Most people think of lactic acid in their muscles during a tough workout. Blood lactate levels represent the balance between lactate production and lactate metabolism. The liver is responsible for the major part of lactate metabolism. Inadequate oxygen delivery and tissue hypoxia, irrespective of the underlying etiology, results in increased lactate generation. Cite Share Subject Physiology - Other Issue Section: Articles Key points Blood lactate concentrations reflect the balance between lactate production and clearance. Glycolysis, gluconeogenesis and pyruvate conversion to and from lactate are linked with NAD + and NADH. GzgQ.